Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy

Fetal and neonatal immune thrombocytopenia (FNIT) is a severe bleeding disorder
in which maternal antibodies cross the placenta and destroy fetal/neonatal platelets.
It has been demonstrated that the neonatal Fc receptor (FcRn) regulates
immunoglobulin G (IgG) homeostasis and plays an important role in transplacental
IgG transport.

BLOOD, 4 NOVEMBER 2010
VOLUME 116, NUMBER 18